Jan-Hendrik (Jannie) Hofmeyr: Distinguished Professor of Biocomplexity and Biochemistry and Co-Director of the Centre for Complex Systems in Transition at the University of Stellenbosch. He has been a member of the Biochemistry Department since 1975. His research of the past 30 years has been in the field of computational systems biology where his main focus has been the understanding of regulatory design of metabolism. He obtained his Ph.D. in 1986 at the University of Stellenbosch after collaborating with Henrik Kacser and the enzymologist Athel Cornish-Bowden. In the late 90s Jannie and his colleagues Jacky Snoep and Johann Rohwer formed the Triple-J Group for Molecular Cell Physiology in the Department of Biochemistry; this research group studies the control and regulation of cellular processes using theoretical, computer modelling and experimental approaches. He has made numerous fundamental contributions to the development of metabolic control analysis and computational systems biology, and with Athel Cornish-Bowden developed both co-response analysis and supply-demand analysis as a basis for understanding metabolic regulation.